Adding a certain compound to certain chemical reactions, such as: 2468-56-6, name is 6-Iodohex-1-yne, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2468-56-6, Formula: C6H9I
To a solution of diisopropylamine (0.86 mL, 6.1 mmol) in anhydrous THF (10 mL) at 0 C was added n-butyllithium (2.5M in hexane) under nitrogen to give a light yellow solution which was stirred at room temperature for 10 mm. Ethyl 2-(1,3,5-trimethyl-1 H-pyrazol-4- yl)acetate (1.00 g, 5.10 mmol) was added at -78 C and the yellowish orange mixture was stirred at -78 C for 1 hr. 6-iodo-1-hexyne (0.78 mL, 5.9 mmol) was added to give orange mixture which was stirred at -78 C for another I hr before the addition of I ,3-Dimethyl- 3,4,5,6-tetrahydro-2(1 H)-pyrimidinone (DMPU). The mixture was slowly warmed to 0 C in 1 hr and water (5 mL) was added to quench the reaction. Ethyl acetate (3x 200 mL) was used to extract the product and the organic layer was washed with saturated aqueous ammonium chloride solution (20 mL), hydrochloric acid (IM, 20 mL), saturated aqueous sodium carbonate solution (20 mL), brine (20 mL), dried over MgSO4 and concentrated in vacuo to give an orange liquid. The crude product was purified by flash column chromatography by elution with 50% ethyl acetate in hexane to give Ethyl 2-(1 ,3,5-trimethyl-1 H-pyrazol-4-yl)oct- 7-ynoate as a pale yellow oil (233 mg, 17%). ESI HRMS, found 277.1919 (C16H25N202), MW, requires 277.1916. 1H NMR (COds, 400 MHz, 300 K) 64.12-4.01 (2H, m), 3.66 (3H, s), 3.37 (1H, dd, J = 8.4, 7.1 Hz,), 2.17 (6H, d, J = 3.8 Hz), 2.13 (2H, td, J = 7.1, 2.5 Hz), 2.07-1.97 (1 H, m), 1.89 (1 H, t, J 2.6 Hz), 1.73-1.64 (1 H, m), 1.54-1.46 (2H, m,), 1.35-1.27 (2H, m), 1.18 (3H, t, J= 7.1 Hz, Hk).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Iodohex-1-yne, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; IMPERIAL INNOVATIONS LIMITED; BELL, Andrew Simon; TATE, Edward William; LEATHERBARROW, Robin John; HUTTON, Jennie Ann; BRANNIGAN, James Antony; (213 pag.)WO2017/1812; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com