Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 202982-67-0, name is 4-Chloro-3-fluoroiodobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 202982-67-0
A few drops of l -chloro-2-fluoro-4-iodobenzene (31.1 g, 121 mmol) in 50 mL of diethyl ether was added to the mixture of magnesium turnings (3.29 g, 136 mmol) and diethyl ether (50 mL) under nitrogen. After the reaction was initiated, the rest of the l-chloro-2-fluoro-4-iodobenzene ether solution was added at room temperature, and the reaction mixture was stirred at the same temperature for 1 h. This grignard reagent solution was added slowly to a solution of tert-butyl 4-(l-cyano-2- methoxy-2-oxoethy lidene)piperi dine- 1-carboxy late (10 g, 35.7 mmol) and copper(I) iodide (1.631 g, 8.56 mmol) in THF (200 mL) at 0 C, and the reaction mixture was stirred at 0 C for 1 h. Saturated ammonium chloride solution (100ml) was added, and the mixture was diluted with 500ml of ethyl acetate. The organic layer was washed with the water and brine solution, dried with the sodium sulphate and concentrated. The crude product was purified via silica gel chromatography eluteing with 20% of ethyl acetate in pet ether to give tert-butyl 4-(4-chloro-3-fluorophenyl)-4-(l-cyano-2-methoxy-2- oxoethyl)piperi dine- 1-carboxy late (12 g, 77%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WU, Yong-Jin; GUERNON, Jason M.; (102 pag.)WO2018/81384; (2018); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com