Application of 4028-63-1, The chemical industry reduces the impact on the environment during synthesis 4028-63-1, name is 2,4,6-Trimethyliodobenzene, I believe this compound will play a more active role in future production and life.
General procedure: Aryl iodide (1 mmol), nucleophile (0.8-1.2 mmol), tris-(2-furyl)-phosphine (TFP) (10 mol percent), tris-dibenzylideneacetonedipalladium (0) (Pd2dba3) (2.5 mol percent), base (2 mmol) and MeCN (20 mL) were combined in a Schlenk tube. After two freeze-pump-thaw cycles, allene gas (0.5 atm) was charged into the Schlenk tube, the mixture thawed and then heated for 16-24 h at 70-80°C with magnetic stirring. After cooling to room temperature and venting excess allene, DCM (10 mL) was added, the mixture filtered, and the filtrate evaporated in vacuo. Column chromatography of the residue afforded the product.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4,6-Trimethyliodobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Dondas, H. Ali; Hempshall, Aiden; Narramore, Sarah; Kilner, Colin; Fishwick, Colin W.G.; Grigg, Ronald; Tetrahedron; vol. 72; 10; (2016); p. 1316 – 1329;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com