Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 626-44-8, name is 1,3,5-Triiodobenzene, A new synthetic method of this compound is introduced below., Formula: C6H3I3
A solution of 1,3,5-triiodobenzene (0.226 g, 0.497 mmol),2-ethynyl-4,6-dimethylpyrimidine (0.229 g, 1.739 mmol),Pd(PPh3)2Cl2(0.034 g, 0.049 mmol), CuI (0.018 g, 0.097 mmol) inEt3N (15 mL) was stirred at 90C for 24 h under nitrogen atmosphere, the TLC monitoring indicated the consumption of startingmaterials. The reaction mixture was cooled,filtered through Celiteand evaporated under reduced pressure. The crude product waspurified by column chromatography on silica gel (EtOH was usedfor thefirst purification followed by a second one with ethyl acetateas eluent) to afford the title compound3as brown solid (0.097 g,42percent). Mp: 230C. IR (cm1, neat): 2962, 2923, 2900, 2172, 1949,1738, 1587, 1535, 1441, 1346, 1251, 1176, 1036, 956, 943, 845, 788,761, 704, 634, 619;1H NMR (300 MHz, CDCl3)d(ppm): 2.52 (s, 18H),7.01 (s, 3H), 7.88 (s, 3H);13C NMR (75 MHz, CDCl3)d(ppm): 24.0,84.3, 89.4, 119.5, 122.8, 136.6, 152.2, 167.3; HRMS: calcd forC30H25N6[MH]469.2141; found 469.2144.
The synthetic route of 626-44-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Martin, Flavia-Adina; Baudequin, Christine; Fiol-Petit, Catherine; Darabantu, Mircea; Ramondenc, Yvan; Ple?, Nelly; Tetrahedron; vol. 70; 15; (2014); p. 2546 – 2555;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com