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Related Products of 202982-67-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202982-67-0, name is 4-Chloro-3-fluoroiodobenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Reference Production Example 4To a solution of 3.0 g of 2-fluoro-4-iodochlorobenzene and 3.6 g of methyl (3, 3, 3-trifluoropropylsulfonyl) acetate in 100 ml of 1,4-dioxane were added 1.40 g of sodium hydride (60% dispersion in paraffin liquid), 242 mg of (dibenzylideneacetone) (chloroform) dipalladium (0) and 368 mg of triphenylphosphine at room temperature, and the mixture was stirred at 800C for 5 days. To the reaction mixture was added 10% hydrochloric acid, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to obtain 1.8 g of methyl (4-chloro-3- fluorophenyl) -(3,3, 3-trifluoropropylsulfonyl) acetate represented by the following formula:1H-NMR (CDCl3, TMS): delta (ppm) 7.43-7.53 (2H, m) , 7.31 (IH, dd) , 5.02 (IH, s), 3.90 (3H, s) , 3.17-3.58 (2H, m) , 2.44- 2.77 (2H, m) .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Chloro-3-fluoroiodobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2009/14268; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com