Synthetic Route of 723294-75-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 723294-75-5 as follows.
To a solution of 13 (50 mg, 0.2mmol) in imL of dry DMF was added 14 (53mg, 0.2mmol), C52C03 (200 mg, 0.2mmoi), Pd(dba)2 (20 mg) and Xantphos (10 mg). The mixture was degassed under vacuo and purged with N2 for several times. Then the mixture was stirred at 110C for 2h, The mixture was diluted with water (2OmL) and extracted with EtOAc (5OmL).The organic layer was washed with brine (2OmL), dried over anhydrous Na2SO4 and concentrated. The crude product was purified by prep-TLC to give the target product Compound 1 (2.8 mg, yield: 4%).LCMS: ith. 445.9(M-t-HY;1IINMR (400 MHz, CDC]3): oe857 (s, I El), .03(s, IH), ?787(s, 111), 7.82-7.83(m, IH),7 71(m IH) 7 8-7 61(m 1H) 7 54(s, 1H) 7 50-7 5(m IH) 7 47- 0 m, I H) 7 30-7 12 (m, 2H), 729-728 (m, 1H.
According to the analysis of related databases, 723294-75-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; LI, Yongguo; (44 pag.)WO2017/173604; (2017); A1;,
Iodide – Wikipedia,
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