Adding a certain compound to certain chemical reactions, such as: 10297-05-9, name is 1-Chloro-4-iodobutane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10297-05-9, Recommanded Product: 10297-05-9
A)Methyl 6-chloro-2-(2-fluorophenyl)-2-(6-methoxy-3-nitropyridin-2-yl)hexanoate (XII)To 9.3 g of sodium hydride at 60percent in oil in suspension in 900 ml of DMF is added at 0° C., dropwise, the mixture of 20 g of 2-chloro-6-methoxy-3-nitropyridine and 19.6 g of methyl 2-fluorophenyl acetate in solution in 100 ml of DMF.The reaction mixture is stirred for 3 h, allowing the temperature to rise to room temperature and then 34 ml of iodochlorobutane are added.The mixture is stirred at RT for 48 h.500 ml of a 5percent aqueous NaHCO3 solution are added and the mixture is extracted with 500 ml of AcOEt.The organic phase is washed with 300 ml of a 5percent aqueous NaHCO3 solution, dried over Na2SO4 and then the solvents are then evaporated under reduced pressure.The residue is purified by silica gel chromatography, eluting with a cyclohexane/ethyl acetate mixture to give the expected compound in the form of a liquid which is used as it is in the next step.
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Reference:
Patent; SANOFI-AVENTIS; US2011/71160; (2011); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com