Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, A new synthetic method of this compound is introduced below., Safety of 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane
2.4. Synthesis of 1-chloro-3-1H,1H,2H,2H-perurooctyl-5,5-dimetylhydantoin (Cl-FODMH)3-1H,1H,2H,2H-perurooctyl-5,5-dimetylhydantoin (FODMH)was synthesized using similar procedures as in the preparation ofODMH. Briey, 3.20 g DMH were dissolved in 30 mL methanol inthe presence of 1.68 g potassium hydroxide. The mixture was keptat 50 C for 30 min. After evaporation of the solvent, the potassiumsalt of DMH was dried in a vacuum oven at 60 C for three days. Theanhydrous salt was then dispersed in 100 mL N,N-dime-thylformamide (DMF) at 95 C for 10 min under constant stirring,after which 11.85 g IFO were added into the mixtures. The reactionwas continued for 4 h at 95 C. At the end of the reaction, theformed KI was ltered off. After the removal of DMF by distillationunder reduced pressure, the residual substance was recrystallizedfrom ethanol. 3-1H,1H,2H,2H-perurooctyl-5,5-dimetylhydantoin(FODMH) was obtained as white powders with a yield of 60.7%(7.22 g).In the preparation of Cl-FODMH, 0.5 g FODMH and 0.74 g tri-chloroisocyanuric acid (TCCA) were dissolved in acetone [10]. Here,TCCA was employed because our screening tests showed that usingchlorine bleach as the chlorination agent could not chlorinateFODMH successfully due to the very hydrophobic nature ofFODMH. The solution was vigorously stirred for 30 min at ambienttemperature. At the end of the reaction, acetone was evaporated,hexane was added to the mixtures, and the insoluble solids wereltered off. After removing hexane from the ltrate by evaporation,Cl-FODMH was obtained as white powders with a yield of 59.2%.
The synthetic route of 2043-57-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lin, Jiajin; Jiang, Fuguang; Wen, Jianchuan; Lv, Wei; Porteous, Nuala; Deng, Ying; Sun, Yuyu; Polymer; vol. 68; (2015); p. 92 – 100;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com