Some common heterocyclic compound, 249647-24-3, name is Methyl 3-bromo-4-iodobenzoate, molecular formula is C8H6BrIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: Methyl 3-bromo-4-iodobenzoate
Example 31Preparation of lambda/-r2-amino-1-(phenylmethyl)ethyll-3-bromo-4-(1-methyl-1/-/-pyrazol- 5-yl)benzamidea) methyl 3-bromo-4-(1-methyl-1 /-/-pyrazol-5-yl)benzoateTo a solution of methyl 3-bromo-4-iodobenzoate (409 mg, 1.2 mmol) in dioxane/H2O (4:1 , 10 ml.) was added K2CO3 (497 mg, 3.6 mmol), tetrakistriphenylphosphine Pd(O) (69 mg, 0.06 mmol) and 5-(5,5-dimethyl-1 ,3,2- dioxaborinan-2-yl)-1-methyl-1 /-/-pyrazole (349 mg, 3.6 mmol). The reaction mixture was heated to 80 C in a sealed tube for 12h and was then partitioned between 6N NaOH and DCM. The pH of the aqueous phase was adjusted to ~3 with 3M HCI and washed several times with DCM. The combined organic fractions were dried (Na2SO4), concentrated under vacuum and used directly without further purification (307 mg, 87%): LC-MS (ES) m/z = 296 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 249647-24-3, its application will become more common.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/121786; (2008); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com