460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C3H4F3I
110 g (760 mmol) of thiobarbituric acid of formula (XI) was added to 360 mL of water at room temperature,System was suspended state,66.9 g (1.67 mol) of sodium hydroxide was added to the system,The system gradually become clear,Plus,Stir at room temperature for 0.5 h.To the system was added 220 ml of N, N-dimethylformamide,Then 340.4 g (1.52 mol) of 1-iodo-3,3,3-trifluoropropane was added to the system,Plus,Heating to 60 C stirring reaction 8h,TLC monitoring to the basic disappearance of raw materials,The reaction is complete,Stop the reaction,Cooling to room temperature,With 2mol / L hydrochloric acid to adjust the pH to 2.5,filter,Washed cake,After solid drying,Beating,Filtered to give 171.5 g of a white solid,I.e. a compound of formula (X)Yield: 94%
The synthetic route of 460-37-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shandong Bainuo Pharmaceutical Co., Ltd.; Zhen Yizhan; Zhang Zhiqiang; Gao Changsong; Lv Wei; Zhang Zhen; (19 pag.)CN105061431; (2017); B;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com