333447-42-0, name is 1,5-Difluoro-2-iodo-4-methylbenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 1,5-Difluoro-2-iodo-4-methylbenzene
A solution of 1,5-difluoro-2-iodo-4-methylbenzene (26, 7.11 g, 28.0 mmol), Zn(CN)2 (1.97 g, 16.8 mmol) and Pd(PPh3)4 (3.23 g, 2.8 mmol) in DMF (40 mL) was heated at 90 C for 1.5 h. The reaction mixture was concentrated in vacuo and the residue was taken in water (400 mL) and extracted with ether (400 mL). The combined organic layer was washed with excess aq ammonium hydroxide solution. The separated organic layers were dried and purified b chromatography to yield purified product which contained triphenylphospine oxide. The crude mixture was further purified by sublimation (45 C, 1 mm/Hg) to yield 27 (1.8 g, 42%) as a colorless solid. 1H NMR (400 MHz, CDCl3) delta 7.47 (t, 1H, J = 8.0 Hz), 6.92 (t, 1H, J = 9.2 Hz), 2.27 (s, 3H).
The synthetic route of 333447-42-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Venkatraman, Srikanth; Velazquez, Francisco; Gavalas, Stephen; Wu, Wanli; Chen, Kevin X.; Nair, Anilkumar G.; Bennett, Frank; Huang, Yuhua; Pinto, Patrick; Jiang, Yueheng; Selyutin, Oleg; Vibulbhan, Bancha; Zeng, Qingbei; Lesburg, Charles; Duca, Jose; Heimark, Larry; Huang, Hsueh-Cheng; Agrawal, Sony; Jiang, Chuan-Kui; Ferrari, Eric; Li, Cheng; Kozlowski, Joseph; Rosenblum, Stuart; Shih, Neng-Yang; George Njoroge; Bioorganic and Medicinal Chemistry; vol. 22; 1; (2014); p. 447 – 458;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com