Related Products of 31827-94-8, A common heterocyclic compound, 31827-94-8, name is 2-Bromo-1-(4-iodophenyl)ethanone, molecular formula is C8H6BrIO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example QC-13b To a solution of (S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxylic acid (6.5 g, 26.1 mmol) in 150 mL of ethyl acetate was added triethylamine (4.0 mL, 28.7 mmol) and Example QC-13a (8.5 g, 26.1 mmol) at 0 C. The resulting mixture was stirred at room temperature overnight. The reaction mixture was filtered. The filtrate was washed with saturated sodium bicarbonate aqueous solution, and brine. The organic layer was dried with MgSO4 and concentrated. The crude product was purified by a flash chromatography (silica gel, 10-40% ethyl acetate/hexanes) to give the product as a white solid Example QC-13b (15.3 g, 85.4%). 1H NMR (500 MHz, CDCl3) delta ppm 1.87-2.01 (m, 1H) 2.01-2.16 (m, 1H) 2.22-2.42 (m, 2H) 3.44-3.58 (m, 1H) 3.59-3.71 (m, 1H) 4.45-4.58 (m, 1H) 5.04-5.50 (m, 4H) 7.27-7.38 (m, 5H) 7.53 (d, J=8.24 Hz, 1H) 7.59 (d, J=8.24 Hz, 1H) 7.85 (dd, J=8.39, 3.81 Hz, 2H). LC/MS: Anal. Calcd. for C21H21INO5 [M+H]+ 494.05; found 494.32.
The synthetic route of 31827-94-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bristol-Myers Squibb Company; US2010/249190; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com