Month: August 2021

Synthetic Route of 69113-59-3, These common heterocyclic compound, 69113-59-3, name is 3-Iodobenzonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Aryl iodide or bromides (1 mmol), ArOH (1 mmol), CuI(20 mol%), and dimethyl di (2-pyridyl)silane (20 mol%) were placed in a small round-bottom flask. DMF (3 mL) and K2CO3(276 mg, 2 mmol) were then added together. The mixture was stirred for 24 h at 100C in nitrogen atmosphere. The reaction mixture was cooled to room temperature. Ethyl acetate(10 mL) and H2O (1 mL) were added and the mixture was stirred. The organic layer was separated and the aqueous layer was extracted twice more with ethyl acetate (10 mL). Combined organic layer was dried overNa2SO4 and filtered. The filtrate was concentrated and the resulting residue was purified by silica gelchromatography and afforded the desired products.

The synthetic route of 69113-59-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Baohua; Shi, Lanxiang; Guo, Ruixia; Liu, Sijie; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 6; (2016); p. 930 – 932;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 5471-81-8, The chemical industry reduces the impact on the environment during synthesis 5471-81-8, name is Methyl 4-iodo-3-methylbenzoate, I believe this compound will play a more active role in future production and life.

(a) Synthesis of methyl 3-methyl-4-(3-ethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyloxy)benzoate In a manner similar to Example 1(a), by the reaction of 2.1 g (8.7 mmol) of 3-ethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthol with 2 g (7.2 mmol) of methyl 3-methyl-4-iodobenzoate, 2.18 g (79%) of the expected methyl ester was obtained in the form of a pale yellow oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-iodo-3-methylbenzoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Centre International de Recherches Dermatologiques Galderma; US6162815; (2000); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 6940-76-7, name is 1-Chloro-3-iodopropane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6940-76-7, HPLC of Formula: C3H6ClI

A reaction flask or vial was charged 4H-benzo[1,4]ox- azin-3-one (1.0 equiv) dissolved in DMF (0.1 g/ml), Cs2CO3(1.5 equiv) and 1 -chloro-3-iodopropane (1.1 equiv). The reaction was stirred in rt for 60-70 h and evaporated to dryness. The reaction was redisolved in H20 and extractedwith EtOAc 3×1 50 ml. The combined organic phases weredried over Na2SO4 and concentrated to a crude that was useddirectly or purified by column chromatography (heptanes/ EtOAc).5,7-Difluoro-4H-benzo[ 1 ,4]oxazin-3-one (0.24 g, 1.3 mmol), Cs2CO3 (1.08 g, 3.3 mmol), and 1-chloro-3-iodo- propane (0.296 g, 1.45 mmol) were mixed according to GP2.Purified by column chromatography (Si02 heptanes/ EtOAc, gradient 0 to 30% EtOAc) to give the title compound (0.17 g, 49%). R1=0.66 (heptanes/EtOAc 1:1); ?H NMR (CDC13) oe 6.67-6.58 (m, 2H), 4.55 (s, 2H), 4.16-4.10 (m, 2H), 3.59-3.52 (m, 2H), 2.21-2.10 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Chloro-3-iodopropane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ACADIA PHARMACEUTICALS, INC.; Skjaerbaek, Niels; Koch, Kristian Norup; Friberg, Bo Lennart Mikael; Tolf, Bo-Ragnar; (70 pag.)US9522906; (2016); B2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Electric Literature of 19099-54-8, A common heterocyclic compound, 19099-54-8, name is 1-Iodo-2-isopropylbenzene, molecular formula is C9H11I, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Cu (I) iodide (38 mg, 0.2 mmol) and potassium carbonate (276 mg, 2.0 mmol) were charged into a screw-capped test tube with Teflon-lined septum. The tube was evacuated and backfilled with argon (3 cycles). tert-Amyl alcohol (2-methyl-2-butanol) (1.0 [ML,] bench grade solvent without degassing and pre-drying), ethylene glycol [(111 GL,] 2.0 mmol, bench grade solvent), 2-isopropyliodobenzene (246 mg, 1.0 mmol) and 2- isopropylbenzenethiol (90% purity, 202 muL, 1.2 mmol) were added by syringes at room temperature. The tube was heated to [100 C] and stirred for 24 hours. The reaction mixture was then allowed to reach room temperature. Ethyl acetate (approx. 5 mL) and dodecane (227 [FIL,] GC standard) were added. The aliquot was analyzed GC. The reaction mixture was then filtered and concentrated. The crude product was purified by column chromatography on silica gel using hexane as eluent to afford colorless oil as the titled product (245 mg, 91% yield). Rf= 0.5 [(HEXANE).’H] NMR (CDC13,300 MHz) 8 7.30 (d, 2 H, [J =] 7.2 Hz), 7.18-7. 24 (m, 2 H), 7.03-7. 05 (m, [4] H), 3.50 (hept, 2 H, J = 6.9 Hz), 1.25 (s, 3 H), 1.23 (s, [3 H). 13C NMR (CDC13,] 75 MHz) 6 149.2, 134.2, 132.1, 127.6, 126.7, 125.9, 30.9, 23.8. IR (neat, [CM”)] 3058,2962, 2929,2867. MS [(EI)] [FILZ] (relative intensity) 270 (100), 211 (90). HRMS [(EI),] Cald. for [CIUSDH22S] 270.1442 ; Found 270.1445.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; WO2004/13094; (2004); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 16932-44-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16932-44-8 name is 2-Iodo-1,3-dimethoxybenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

at -30 add isopropyl magnesium chloride (2.0M, 5.0mL, 10.0mmol) in THFTo compound 4 (2.64g, 10.0mmol) in anhydrous THF solution (30mL). The temperature was raised to 15 Thereafter, the mixture was stirred for 1 hour. The reaction solution was cooled to -78 , and phosphorus trichloride (0.69g,5.0mmol) were added thereto. At -78 deg.] C the resulting mixture was stirred for 1 hour. The solvent was removed under reduced pressure,To obtain a compound 5.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Iodo-1,3-dimethoxybenzene, and friends who are interested can also refer to it.

Reference:
Patent; Japan Polypropylene Corporation; Tanna, Akirahisashi; Sato, Naomasa; Konishi, Yohei; Oishi, Yasuo; (27 pag.)CN105593235; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Application of 19099-54-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19099-54-8, name is 1-Iodo-2-isopropylbenzene belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

l-Iodo-2-isopropylbenzene (1.5 g, 6.1 mmol) was suspended with silver sulfate (1.0 g, 3.1 mmol), concentrated sulfuric acid (5.5 mL), water (0.6 mL), and bromine (0.3 mL, 6.4 mmol). The triphasic solution was stirred at room temperature for 1 h. The mixture was poured into ether (150 niL) and water (75 rnL). The solids were filtered and the layers separated. The organic layer was concentrated in vacuo and the residue purified by preparatory HPLC to afford the title compound as a white solid (189 mg, 10%).[0257] 1H NMR (500 MHz, DMSO-J6) delta 1.18 (d, J = 6.8 Hz, 6H), 3.07 (qn, J = 6.8 Hz, IH), 7.15 (dd, J = 8.4, 2.5 Hz, IH), 7.46 (d, J = 2.4 Hz, IH), 7.75 (d, J= SA Hz, IH) 2D NOE (500 MHz, DMSO-J6): crosspeak between delta 1.18 and 7.46

The synthetic route of 1-Iodo-2-isopropylbenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TARGEGEN INC.; WO2009/55674; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Related Products of 19094-56-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19094-56-5, name is 2-Chloro-5-iodobenzoic acid belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: The 25-OCH3-PPD (1 equiv) was added to a solution of DCC (2 equiv), DMAP (0.2 equiv) and different aromatic groups (1 equiv) in dry dichloromethane and the reaction mixtures were shaken for 24 h. The solvent was removed under reduced pressure to give a white solid. The white solid was dissolved in ethyl ether and washed with NaHCO3 (5%), dried (MgSO4) and concentrated under reduced pressure to give the crude product. The crude products were chromatographed by silica gel and eluted with petroleum ether/ethyl acetate (4:1, 2:1 and 1:1) to give the pure products 1b, 1c and 1a. Using the same procedure described above for the other compounds.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloro-5-iodobenzoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Qu, Fan-Zhi; Xiao, Sheng-Nan; Wang, Xu-De; Zhang, Yan; Su, Guang-Yue; Zhao, Yu-Qing; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 189 – 193;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19094-56-5, name is 2-Chloro-5-iodobenzoic acid, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H4ClIO2

5g of 2-chloro-5-iodobenzoic acid and 30mL of methylene chloride were added into a 100mL reaction flask under nitrogen atmosphere, and then 0.13g of N, N-dimethylformamide was added, and 2.7g Oxalyl chloride, incubated at the end of the reaction dropwise 1h, and then warmed to 35-40 C for 2-3hrs, after the end of the reaction vacuum distillation, steamed to solvent-free fractions, and then added 30mL dichloromethane vacuum distillation, to be dried residual oxalyl chloride , Pale yellow viscous substance 5.3g, is 2-chloro-5-iodobenzoyl chloride, yield 100%.

According to the analysis of related databases, 19094-56-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chongqing Boteng Pharmaceutical Technology Co., Ltd.; Lin Wenqing; Zheng Hongjie; Lin Chuanhua; Shen Chenjian; Liu Shouxuan; (6 pag.)CN106316803; (2017); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Adding a certain compound to certain chemical reactions, such as: 175278-00-9, name is 1-Iodo-2-(trifluoromethoxy)benzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 175278-00-9, HPLC of Formula: C7H4F3IO

General procedure: A sealed tube containing a magnetic stirring bar was charged with aryl iodide (1.0 mmol), Te (0.13 g, 1.0 mmol), KOH (0.11 g, 2.0 mmol) and DMSO (2 mL) under nitrogen. The reaction mixture was heated in an oil bath at 110 C and stirred at this temperature for 10 h. The progress of the reaction was monitored by TLC via syringe. After the reaction was complete, the reaction mixture was allowed to cool, and treated with CH2Cl2 and H2O. The organic layer was washed with sat. NH4Cl and brine solution, dried with Na2SO4 and concentrated under vacuum. The residue was purified by column chromatography on silica gel with an eluent consisting of hexanes and ethyl acetate to affording the corresponding diaryl tellurides in good yields.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Iodo-2-(trifluoromethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Zhang, Shaozhong; Kolluru, Lalitha; Vedula, Souseelya K.; Whippie, Drew; Jin, Jin; Tetrahedron Letters; vol. 58; 37; (2017); p. 3594 – 3597;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com

Synthetic Route of 69113-59-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69113-59-3, name is 3-Iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step-1: To the solution of compound obtained in step A of above example (1.4 g, 1.23 mmol) in DMF (40 ml) was added cesium carbonate (0.63 g, 3.2 mmol), bis-triphenylphosphine Palladium (II) chloride (0.10 g, 0.13 mmol), cuprous Iodide (0.05 g, 0.26 mmol) followed by 3-iodobenzonitrile (0.29 g, 1.27 mmol). The reaction mixture was stirred at 25-30 C. temperature under nitrogen atmosphere for 12 hrs. it was quenched with addition of ice-cold water (15 ml) to provide a suspension. Solid was filtered & dried under vacuum. The solid was purified by using silica gel column chromatography (20% ethyl acetate-Hexane) to provide step-1 product as a solid in 33% (0.5 g) yield. Mass: m/z: 1198 (M+1).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodobenzonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sindkhedkar, Milind Dattatraya; Desai, Vijaya Narayan; Loriya, Rajesh Maganlal; Patel, Mahesh Vithalbhai; Trivedi, Bharat Kalidas; Bora, Rajesh Onkardas; Diwakar, Santosh Devidas; Jadhav, Ganesh Rajaram; Pawar, Shivaji Sampatrao; US2009/247478; (2009); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com