34883-46-0, name is 1-Iodo-2-phenoxybenzene, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Formula: C12H9IO
Synthesis of 1-(2,6-diisopropylphenyl)-3-(2-methoxyphenyl)imidazolidin-2-one To a 200 mL Schlenk flask equipped with a magnetic stirbar was added copper (I) iodide (0.928 g, 4.87 mmol, 0.3 equiv.), K3PO4 (6.89 g, 32.5 mmol, 2 equiv.), 1-iodo-2-phenoxybenzene (2.11 mL, 16.2 mmol, 1 equiv.), and 1-(2,6-diisopropylphenyl)imidazolidin-2-one (4.0 g, 16.2 mmol, 1 equiv.). The vessel was sealed with a septum and purged with nitrogen. Subsequently, N,N’-dimethylethylenediamine (1.05 mL, 9.74 mmol, 0.6 equiv.) and N,N-dimethylacetamide (65 mL) were added via syringe. The reaction was placed into an aluminum heating block preheated to 130 C. and stirred for 24 h. After cooling to room temperature, the material was poured onto diethyl ether (250 mL) and washed with water (2*250 mL). The combined aqueous layers were back extracted with diethyl ether (1*250 mL), dried over MgSO4, and filtered. The solution was concentrated via rotary evaporation. Adsorption onto silica gel, purification via flash column chromatography (ISCO, 220 g silica, 20-30% EtOAc in hexanes gradient), and concentration via rotary evaporation yielded the product as a white solid (5.03 g, 92% yield). 1H NMR (400 MHz, Chloroform-d) delta 7.44-7.38 (m, 1H), 7.31 (dd, J=8.3, 7.1 Hz, 1H), 7.23-7.16 (m, 3H), 7.00-6.93 (m, 2H), 4.01-3.91 (m, 2H), 3.87 (s, 3H), 3.79-3.65 (m, 2H), 3.16 (hept, J=6.9 Hz, 2H), 1.28 (d, J=6.1 Hz, 6H), 1.26 (d, J=6.1 Hz, 6H). 13C NMR (101 MHz, Chloroform-d) delta 158.72, 155.22, 148.25, 133.74, 129.23, 128.62, 128.54, 127.53, 123.97, 120.93, 112.33, 55.72, 46.73, 45.58, 28.62, 24.61, 24.27. HRMS (ESI) Calculated for C22H28N2O2: [M+H]+: 353.2224. found 353.2229.
The synthetic route of 34883-46-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DOW GLOBAL TECHNOLOGIES LLC; Klosin, Jerzy; Fontaine, Philip P.; Figueroa, Ruth; Pearson, David M.; Senecal, Todd D.; (74 pag.)US2016/311837; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com