Some common heterocyclic compound, 13421-13-1, name is 4-Chloro-2-iodobenzoic acid, molecular formula is C7H4ClIO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 13421-13-1
3.35 g (153.18 mmol) of 4,5-dimethyl-pyrrole-3-carboxylate prepared according to the literature (Synthetic uses of tosylmethyl isocyanide (TosMIC) Organic Reactions (Hoboken, NJ, United States) ( 2001), 57, No. 418) and 4,63g (16.4 mmol) of 4-chloro-2- iodo-benzoic acid are dissolved in 50 ml of acetonitrile.copper powder was added thereto (45 mu) (280 mg, 4.37 mmol) and cesium carbonate (14.25 g, 43.74 mmol).The reaction medium is refluxed for 12 h.The progress of the reaction is monitored by liquid chromatography (LC).The suspension was allowed to return to ambient temperature, then it is filtered, washed with acetonitrile and evaporated to dryness.The residue is taken up in ethyl acetate.The solution was then washed with 1M hydrochloric acid, then with a saturated solution of sodium chloride, dried over magnesium sulfate, filtered and then evaporated to dryness.The compound thus obtained is purified on silica gel column using dichloromethane and ethanol as solvents.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 13421-13-1, its application will become more common.
Reference:
Patent; France Servier Pharmaceuticals; p, Casara; T, Le Diguaher; J-M, Henlin; J-B, Starck; A, Le Tiran; G, De Nanteuil; O, Geneste; J·E·P, Davidson; J·B, Murray; I-J, Chen; C, Walmsley; C·J, Graham; S, Ray; D, Maddox; S, Bedford; (116 pag.)CN105408321; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com