Adding a certain compound to certain chemical reactions, such as: 51839-15-7, name is Dimethyl 5-iodoisophthalate, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51839-15-7, Application In Synthesis of Dimethyl 5-iodoisophthalate
To a solution of dimethyl 5-iodoisophthalate (13 g, 40.6 mmol) in 100 mL THF was added 2-cyano- phenyl zinc bromide (97.5 mL, 48.7 mmol, 0.5 M THF) and tetrakis (triphenylphosphine) palladium (214 mg, 0.2 mmol) and the reaction mixture was stirred at room temperature for 2 h. The precipitated solid was filtered, the filtrate was diluted with MEOH to provide after filtration of a second crop dimethyl 5- (2-CYANOPHENYL) isophthalate which was hydrolyzed to the corresponding monoacid 2′-cyano-5- (methoxycarbonyl)-1, 1-BIPHENYL-3-CARBOXYLIC acid following a similar procedure as described in intermediate A preparation, step C. LH NMR (400 MHz, d6-DMSO) 8 13.55 (br s, 1H), 8.60-8. 55 (m, 1H), 8.38-8. 31 (m, 2H), 8.02 (d, J=8. 3HZ, LH), 7.85 (td, J = 8. 3 Hz, 1. 5 HZ 1H), 7.75 (d, J=8. 3HZ, 1H), 7. 66 (td, J = 8.3 Hz, 1.5 Hz 1H), 3.93 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 5-iodoisophthalate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK & CO., INC.; WO2005/32471; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com