Related Products of 2043-57-4, These common heterocyclic compound, 2043-57-4, name is 1,1,1,2,2,3,3,4,4,5,5,6,6-Tridecafluoro-8-iodooctane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The entire procedure including the isolation and characterization of the product was performed under an inert atmosphere (N2). n-BuLi (0.94 mL, 2.4 mmol, 1.0 equiv, 2.5 mol/L solution in hexane) was added at r.t. to a solution of Ph2PH (438 mg, 2.40 mmol, 1.0 equiv) in abs THF (2 mL). After stirring the mixture for 5 min at 23 C, perfluorinated iodide 19 (1.12 g, 2.40 mmol, 1.0 equiv) was added and the mixture was further stirred for 17 h at 23 C. The mixture was then filtered using a reversible frit and the resulting solution was evaporated to furnish the product 20 (1.11 g, 2.09 mmol, 89%) as an off-white solid; mp 40 C. IR (ATR): 3072 (w), 1482 (w), 1439 (w), 1364 (w), 1235 (m), 1182 (s), 1139 (s), 1121 (m), 1070 (m), 1028 (w), 925 (w), 847 (w), 746 (m), 735 (m), 723 (m), 693 cm-1 (s). 1H NMR (300 MHz, CDCl3): delta = 2.05-2.23 (m, 2 H), 2.24-2.37 (m, 2 H), 7.33-7.41 (m, 6 H), 7.42-7.51 (m, 4 H). 31P{1H} NMR (203 MHz, CDCl3): delta = -16.05 (s). The 13C NMR spectrum was in accordance with literature data. HRMS (ESI): m/z [M + Na]+ calcd for C20H14F13NaP: 555.0523; found: 555.0529.
The synthetic route of 2043-57-4 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Alpers, Torben; Muesmann, Thomas W. T.; Temme, Oliver; Christoffers, Jens; Synthesis; vol. 50; 17; (2018); p. 3531 – 3539;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com