Electric Literature of 75581-11-2, A common heterocyclic compound, 75581-11-2, name is 4-Iodo-1-methoxy-2-methylbenzene, molecular formula is C8H9IO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a typical reaction, styrene (1.0 mmol) and aryl halide (1.5 mmol) were reacted in a homogeneous mixture of toluene and PEG-600 (20 ml, 3:1) in the presence of 3 mol % of Cl2PdPEGD catalyst(34.4 mg) and Cs2CO3 (1.5 mmol), under a nitrogen atmosphere at 80 C for 5 h until complete consumption of aryl halide. The reaction progress was monitored by TLC and GC analysis. The mixture was cooled to room temperature and 20 ml of n-hexane was added to separate lower catalyst-philic PEG phase from upper product phase. The product was isolated by decantation and evaporation of solvents under vacuum. Catalyst-philic PEG phase containing polyether palladium catalyst was subjected to reuse by charging with the same amount of the substrates styrene (1.0 mmol) and aryl halide (1.5 mmol), Cs2CO3 (2.0 mmol) and toluene. The identity and purity of the products were confirmed by GC and GC-MS.
The synthetic route of 75581-11-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Sawant, Dinesh; Wagh, Yogesh; Bhatte, Kushal; Panda, Anil; Bhanage, Bhalchandra; Tetrahedron Letters; vol. 52; 18; (2011); p. 2390 – 2393;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com