Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6940-76-7, name is 1-Chloro-3-iodopropane, A new synthetic method of this compound is introduced below., Computed Properties of C3H6ClI
Step B: To a solution of 3,4-difluorobenzenesulfinic acid (2.5 g, 14.0 mmol) in dimethyl formamide (20 mL) was added 1-chloro-3-iodopropane (4.46 mL, 42.1 mmol) and N-ethyl-N-isopropylpropan-2-amine (2.82 mL, 15.4 mmol) and the reaction was stirred overnight at ambient temperature. The reaction was poured into water and extracted into diethyl ether. The combined organic layers were washed with water, brine, dried over MgS04, filtered and concentrated in vacuo. The material was purified over silica gel (4: 1 hexanes/EtOAc) to yield 4-(3-chloropropylsulfonyl)-1,2-difluorobenzene (2.8 g, 80%).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ARRAY BIOPHARMA INC.; AICHER, Thomas Daniel; BENSCIK, Josef Roland; BOYD, Steven Armen; CONDROSKI, Kevin Ronald; FELL, Jay Bradford; FISCHER, John Peter; HINKLIN, Ronald Jay; PRATT, Scott; SINGH, Ajay; TURNER, Timothy M.; WO2013/66869; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com