Reference of 628-77-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 628-77-3, name is 1,5-Diiodopentane, This compound has unique chemical properties. The synthetic route is as follows.
Example 15 (n=5); (a) 1, 1″- [ (Pentane-1, 5-diyl) dioxyjbisf (11S, llaS)-10- (tert- butyloxycarbonyl)-7-methoxy-11- (tetrahydro-pyran-2-yloxy)- 1, 2, 3, 10, 11, 11a-hexahydro-5H-pyrrolo [2, 1-c] [1, 4] benzodiazepine-5- one] (15c); 1,5-Diiodopentane (72.2 mg, 0.22 mmol, 0.5 equiv) was added to the mixture of monomer 14 (0.2 g, 0.44 mmol, 1.0 equiv) and potassium carbonate (0.98 mmol, 2.2 equiv) in dry DMF (30 mL), and the resulting mixture was heated to 90C under a nitrogen atmosphere for 5 h. Removal of excess solvent under reduced pressure afforded a crude solid, which was subjected to flash column chromatography (SiO2, 50% EtOAc-hexane) to afford the dimerized compound 15c (212 mg, 0.21 mmol, 98% yield, mixture of diastereomers from THP protecting group) as a solid: [a] 20D = +40 (c = 0.22, CHCl3) ; 1H NMR (CDC13, 400 MHz) : 5 1. 21-1. 83 (m, 64H, 14-H, Boc, THP), 1. 88-2. 18 (m, 24H, 1-H, 2-H, 13-H), 3.41-3. 73 (m, 16H, 3-H, 11a-H, THP), 3.84-4. 10 (m, 24H, 12-H, 7-OMe, THP), 4.97-5. 15 (m, 4H, THP), 5.66-5. 75 (d, 2H, 11-H), 5.77-5. 89 (d, 2H, 11-H), 6.50 (s, 2H, 9- H), 6.84 (s, 2H, 9-H), 7.17 (s, 2H, 6-H), 7.21 (s, 2H, 6-H); 13C NMR (CDCl3, 400 MHz): 6 19.9, 20.5, 21.0, 22.7, 23. 1, 23.3, 25.3, 28. 1, 28.2, 28.9, 29.1, 31.0, 31.3, 46.3, 56.0, 56.1, 60.0, 60.1, 63.4, 64.6, 68.7, 69. 0, 80. 9, 81. 3, 88.2, 91.2, 95.7, 100.4, 110.2, 110.7, 114.5, 115.0, 126.3, 129. 7, 129. 8, 148.5, 148.8, 150.0, 155.1, 167.4, 167.6 ; IR (neat): 3431,2945, 1704, 1643, 1604,1513, 1453, 1432, 1327,1271, 1202,1163, 1023cm-1 ; MS (FAB) m/z (relative intensity) 987 ([M + Na]+., 37), 965 (M +., 100), 763 (92), 863 (75), 982 (49).
The chemical industry reduces the impact on the environment during synthesis 1,5-Diiodopentane. I believe this compound will play a more active role in future production and life.
Reference:
Patent; SPIROGEN LIMITED; WO2005/85259; (2005); A2;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com