Synthetic Route of 627-31-6, The chemical industry reduces the impact on the environment during synthesis 627-31-6, name is 1,3-Diiodopropane(stabilized with Copper chip), I believe this compound will play a more active role in future production and life.
General procedure: The mixture of 4-methylpiperazine-1-carbodithioate (2.21 gm, 11.16 mmol) and diiodomethane (0.3 mL, 3.72 mmol) in CH3CN (20 mL) was stirred at room temperature for overnight. The reaction mixture was concentrated under reduced pressure, crude product was treated with water (10 mL) and extracted with EtOAc (10 * 3 mL). EtOAc layer was washed with water (5 * 3 mL) and combined organic layers were dried on anhydrous sodium sulfate, filtered, and concentrated. The crude product was purified over column chromatography (100-200 mesh) using MeOH/CHCl3 as eluent to afford compound as white solid (0.76 g, 56%); 4.1.53 Propane-1,3-diyl bis(4-(3-cyanopropyl)piperazine-1-carbodithioate) (56) The title compound was synthesized from sodium 4-(3-cyanopropyl)piperazine-1-carbodithioate and diiodopropane in 56% yield as white solid; mp: 118-120 C; IR (KBr) nu (cm-1): 2942, 2823, 2248, 1646; 1H NMR (300 MHz, CDCl3 + CCl4): delta 4.34-4.05 (8H, m), 3.40 (4H, t, J = 7.1 Hz), 2.55-2.42 (16H, m), 2.16-2.07 (2H, m), 1.88-1.79 (4H, m); 13C NMR (75 MHz, CDCl3 + CCl4): delta 196.5 (C=S), 119.1, 55.9, 52.6, 50.7, 35.9, 28.2, 22.7, 15.0; ESI-MS: (m/z)499 (MH+); Anal. (%) calcd. for C21H34N6S4: C, 50.57; H, 6.87; N, 16.85; found C, 50.68; H, 6.94; N, 16.75.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Diiodopropane(stabilized with Copper chip), other downstream synthetic routes, hurry up and to see.
Reference:
Article; Lal, Nand; Jangir, Santosh; Bala, Veenu; Mandalapu, Dhanaraju; Sarswat, Amit; Kumar, Lalit; Jain, Ashish; Kumar, Lokesh; Kushwaha, Bhavana; Pandey, Atindra K.; Krishna, Shagun; Rawat, Tara; Shukla, Praveen K.; Maikhuri, Jagdamba P.; Siddiqi, Mohammad I.; Gupta, Gopal; Sharma, Vishnu L.; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 275 – 290;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com