Electric Literature of 6940-76-7, These common heterocyclic compound, 6940-76-7, name is 1-Chloro-3-iodopropane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a mixture of 1-chloro-3-iodopropane (6.133 g, 0.03 mol) and NaH (3 g, 0.075 mol) in THF (25 ml) at 0C, phenothiazine (5 g, 0.025 mol) in THF (25 ml) was added. The mixture was stirred at room temperature for 9 h. After work-up, 10-(3-chloropropyl)-10H-phenothiazine was obtained in 37% yield.
Statistics shows that 1-Chloro-3-iodopropane is playing an increasingly important role. we look forward to future research findings about 6940-76-7.
Reference:
Article; Li, Na; Qu, GuoJing; Xue, JingNa; Li, Xiao; Zhao, Xuan; Yan, YeHao; Gao, DongFang; Zhang, Lu; Wang, Peng; Zhang, Ming; Zhao, BaoXiang; Miao, JunYing; Lin, ZhaoMin; Bioorganic and Medicinal Chemistry; vol. 27; 13; (2019); p. 2845 – 2856;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com