Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 460-37-7, name is 1,1,1-Trifluoro-3-iodopropane, A new synthetic method of this compound is introduced below., category: iodides-buliding-blocks
5.0 g (21.0 mmol) of the compound from Ex. 165A and 7.25 g (52.5 mmol) of potassium carbonate were stirred in a mixture of 95 ml acetonitrile and 15 ml of DMF at RT for 15 before 14.1 g (63.0 mmol) 1,1,1-trifluoro-3-iodopropane added .The reaction mixture was stirred at a temperature of 78 C for about 16 h.After cooling to RT was diluted with 500 ml ethyl acetate and washed successively twice with 100 ml of water and once with 50 ml of saturated sodium chloride solution.After drying over anhydrous sodium sulfate, was filtered and the filtrate concentrated to dryness.The crude product was purified by chromatography (80 g silica gel, eluent: heptane / ethyl acetate 100: 0-> 60:40).After concentrating the product fractions and drying the residue 2.99 g (42% d. Th.) The title compound obtained.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; HAERTER, MICHAEL; DELBECK, MARTINA; KALTHOF, BERND; LUSTIG, KLEMENS; LINDNER, NIELS; KAST, RAIMUND; WASNAIRE, PIERRE; SUESSMEIER, FRANK; (372 pag.)TW2016/7950; (2016); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com