Adding a certain compound to certain chemical reactions, such as: 450412-29-0, name is 1-Bromo-3-fluoro-2-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 450412-29-0, Computed Properties of C6H3BrFI
Bromo-3-fluoro-2-iodobenzene (100 g, 333.5 mmol),5-Chloro-2-methoxyphenylboronic acid (62.2 g, 333.5 mmol) was dissolved in tetrahydrofuran (800 mL). To this was added a 2 M solution of sodium carbonate (500 mL)Tetrakis (triphenylphosphine) palladium (0) [Pd (PPh3) 4] (7.7 g, 6.7 mmol) was added and refluxed for 12 hours. After the reaction was completed, the mixture was cooled to room temperature, and the resulting mixture was extracted three times with water and toluene.The toluene layer was separated and dried over magnesium sulfate. The filtrate was distilled under reduced pressure, and the resulting mixture was recrystallized three times using chloroform and ethanol to obtain Compound A-1 (53.7 g, yield 51%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-3-fluoro-2-iodobenzene, and friends who are interested can also refer to it.
Reference:
Patent; LG Chem, Ltd.; Jeong Min-u; Lee Dong-hun; Huh Jeong-o; Jang Bun-jae; Huh Dong-uk; Han Mi-yeon; (48 pag.)KR2018/61075; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com