Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2265-91-0, name is 1,3-Difluoro-5-iodobenzene, A new synthetic method of this compound is introduced below., Safety of 1,3-Difluoro-5-iodobenzene
PotassI.um phosphate (1.9 g, 8.7 mmol), trI.s(dI.benzylI.deneacetone)dI.palladI.um (0.27 g, 0.29 mmol), Xantphos (0.17 g, 0.29 mmol) and 3,5-dI.fluoroI.odobenzene (1.5 g, 6.4 mmol) were addedsuccessI.vely to a mI.xture of ethyl 2-aminothI.azole-4-carboxylate (1.0 g, 5.8 mmol) I.n a mI.xture of 9 ml of toluene and 3 ml of water. The mI.xture was flushed wI.th argon for 20 mins, then heated I.n the mI.crowave to 140 C for 1 h. The reactI.on mI.xture was dI.luted wI.th water and extracted wI.th ethyl acetate. The organI.c layer was washed wI.th saturated aqueous sodI.um bI.carbonate solutI.on and water, drI.ed over magnesI.um sulfate and evaporated under reduced pressure. The resI.due was purI.fI.ed bychromatography on sI.lI.ca gel, usI.ng ethyl acetate and cyclohexane as eluents, to delI.ver ethyl 2-(3,5- dI.fluoroanI.lI.no)thI.azole-4-carboxylate (0.16 g, 0.56 mmol). 1H-NMR (400 MHz, CDCl3): oe = 1.41 (t, 3H), 4.40 (q, 2H), 6.54 (t, 1H), 6.95 (d, 2H), 7.63 (s, 1H)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SYNGENTA PARTICIPATIONS AG; JEANMART, Stephane, Andre, Marie; ZAMBACH, Werner; RENDINE, Stefano; LAMBERTH, Clemens; BEAUDEGNIES, Renaud; POULIOT, Martin; BONVALOT, Damien; (73 pag.)WO2017/207362; (2017); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com