These common heterocyclic compound, 61272-76-2, name is 4-Fluoro-2-iodoaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 61272-76-2
General procedure: To a cooled solution of KOt-Bu (3,7 g, 30 mmol) in DMF (50 mL) was added dropwise at ?60 °C a solution of the appropriate 2-iodoaniline (9.6 mmol) in DMF (3 mL) and the nitroarene (9.6mmol) in DMF (8 mL). The mixture was stirred at ?60 °C for 0.5h then the temperature was raised slowly to ?30 °C, and the reaction was continued for an additional 1 h, poured into sat.NH4Cl solution (200 mL) and extracted with EtOAc. The extract was washed with H2O, brine, and dried with Na2SO4. After evaporation,the crude product mixture was subjected to column chromatography (SiO2, hexane?toluene). For analytical data, seethe Supporting Information.
The synthetic route of 4-Fluoro-2-iodoaniline has been constantly updated, and we look forward to future research findings.
Reference:
Article; Trawczy?ski, Adam; Telega, Magdalena; Wrobel, Zbigniew; Synlett; vol. 26; 10; (2015); p. 1352 – 1356;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com