Adding a certain compound to certain chemical reactions, such as: 2265-91-0, name is 1,3-Difluoro-5-iodobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2265-91-0, name: 1,3-Difluoro-5-iodobenzene
In a nitrogen atmosphere, carbazole and potassium tert-butoxide powder were dissolved in 20 mL of anhydrous dimethyl sulfoxide solution, and after mixing well, the reaction temperature rose to 120 C. After the temperature was stabilized, The solution of 1-iodo-3,5-difluorobenzenein anhydrous dimethyl sulfoxide was heated to 140 C after the dropwise addition, and the reaction time was 2 hours. Among them, 1-iodo-3,5-difluorobenzene, carbazole, and tert-butanol The molar ratio of potassium is 1: 2.1: 2.1; the mixed solution is cooled to room temperature and extracted, dried, and rotary solvent is used to remove excess solvent to obtain a crude product. The crude product was separated and purified by column chromatography to obtain compound DCzB-I. The eluent was chloroform: n-hexane = 1: 10 (volume ratio), and the yield was 75%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Difluoro-5-iodobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Fuzhou University; Guo Zhiyong; Xiao Hui; Lou Yuheng; Han Mingxi; (11 pag.)CN110272379; (2019); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com