Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13329-40-3, name is 1-(4-Iodophenyl)ethanone, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-(4-Iodophenyl)ethanone
To a clear dark solution of l-(4-iodophenyl)ethanone (1.046 kg, 4.251 mol, 1 equiv.) in DCM (8 L) was charged (dropwise) bromine (228 ml, 4.45 mol, 1.047 equiv.) over the period of 30 to 45 min at the ambient temperature. The reaction was slightly exothermic (temperature incresed to about 20-25 C) and released a lot of hydrogen bromide gas as the by-product. The reaction was considered as complete after 3 to 4 hrs as indicated by HPLC (typically ~7% starting material, -10% di-bromo by- product, and ~83%> desired mono-bromo product, all in area%> by HPLC). It was then quenched and neutralized by aqueous NaHC03solution wash (4 L), followed by brine wash (3 L). Upon drying over Na2S04, it is rotavapped and solvent swapped to THF and the desired product was crystallized from THF (final volume about 2 L) at from 50C to 20C to afford the 1st crop: 340 g (98% HPLC purity); by concentrating the mother liqor to about half-volume to afford the 2nd crop: 426 g (98%o HPLC purity); by further concentating and addition of hexanes (i.e.,THF/hexanes, 1 : 1) to afford the 3rd crop: 339 g (97+% HPLC purity). The combined crystal title compound was 1.105 kg (80% yield). 1H NMR (500 MHz, CDC13): 7.88 (d, 2 H), 7.70 (d, 2 H), 4.42 (s, 2 H).
According to the analysis of related databases, 13329-40-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; TANG, Datong; XU, Guoyou; PENG, Xiaowen; YING, Lu; WANG, Ce; CAO, Hui; LONG, Jiang; KIM, In, Jong; WANG, Guoqiang; QIU, Yao-ling; OR, Yat, Sun; WO2013/59281; (2013); A2;,
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