Adding a certain compound to certain chemical reactions, such as: 202865-85-8, name is 1-Bromo-4-iodo-2-methylbenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 202865-85-8, COA of Formula: C7H6BrI
Under an argon atmosphere, Intermediate 6 (1.20 g, 2.40 mmol),1-Bromo-4-iodo-2-methylbenzene (Intermediate 11) (852 mg, 2.88 mmol)(1.68 g, 4.80 mmol, manufactured by Wako Pure Chemical Industries, Ltd.) and copper iodide (91.4 mg, 0.48 mmol, 0.35 mmol) were added to a solution of L-proline (110 mg, 0.96 mmol; manufactured by Wako Pure Chemical Industries, : Manufactured by Wako Pure Chemical Industries, Ltd.) Dimethylformamide (2.4 ml, manufactured by Wako Pure Chemical Industries, Ltd.) was stirred under an argon atmosphere for 48 hours, At 110 CAnd heated.Next, after cooling to room temperature, a saturated aqueous solution of ammonium chloride (30 ml) and dichloromethane (100 ml) were added to the reaction mixture, followed by liquid separation. The organic layer was dried over magnesium sulfate and the residue was purified by silica gel column chromatography (dichloromethane 20%, hexane 80%) to obtain Intermediate 12 as pale yellow crystals (1.43 g, yield 89%)
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Reference:
Patent; Kokuritsu Daigaku Hojin Kyushu Daigaku; Kaji, Hironori; Suzuki, Hajime; Suzuki, Katsuaki; Oheiwa, Hajime; Wakamiya, Atsushi; Fukushima, Tatsuya; Suzuki, Huritz; Murata, Yaseujiro; Sieje, Kacheuyuki; Adachi, Jihaya; (48 pag.)KR2015/123907; (2015); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com