Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18698-96-9, name is 2-(2-Iodophenyl)acetic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 2-(2-Iodophenyl)acetic acid
General procedure: A 50 mL, round-bottom flask equipped with a magnetic stir bar was charged with carboxylic acid (2 equiv), HOBT (2 equiv) and EDCI (2 equiv). The reagents were dissolved in DCM and the solution was allowed to stir for 15 min. Subsequently, different amino compounds (11-13) (1 equiv) and TEA (5 equiv) were added to the reaction vessel and the solution was allowed to react at 25 °C for 8 h. Upon completion, the solvent was removed under reduced pressure and the residue was purified by flash chromatography (SiO2, DCM: MeOH = 20:1) to afford corresponding compounds 14a-14k.
The synthetic route of 18698-96-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Tang, Le; Ren, Jing; Ma, Yuchi; Wang, Xin; Chen, Lin; Shen, Jingkang; Chen, Yue-Lei; Xiong, Bing; Tetrahedron Letters; vol. 57; 21; (2016); p. 2311 – 2314;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com