699016-40-5, name is 2-Fluoro-4-iodobenzaldehyde, belongs to iodides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2-Fluoro-4-iodobenzaldehyde
Under nitrogen at room temperature, to a solution of 2,2,2-trifluoro-N-[(1R)-2-(4-mercaptophenyl)-1-methylethyl]acetamide (4.0 g) in N,N-dimethylformamide (40 ml) was added 2-fluoro-4-iodobenzaldehyde (4.18 g) and potassium carbonate (2.31 g), and the mixture was stirred at 60 C. for 2 hours.The resulting mixture was poured into water and the aqueous mixture was extracted with ethyl acetate.The organic layer was washed successively with water (two times) and brine, dried over anhydrous magnesium sulfate and evaporated under reduced pressure.The residue was purified by column chromatography on silica gel (chloroform/ethyl acetate=10:1) to give 2,2,2-trifluoro-N-[(1R)-2-[4-[(2-formyl-5-iodophenyl)thio]phenyl]-1-methylethyl]acetamide (5.02 g). (+)ESI-MS (m/z): 516 (M+Na)+
The synthetic route of 699016-40-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; US2004/106653; (2004); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com