Adding a certain compound to certain chemical reactions, such as: 6940-76-7, name is 1-Chloro-3-iodopropane, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6940-76-7, COA of Formula: C3H6ClI
To a suspension of NaH (1.10 g, 60 % in mineral oil, 27.5 mmol) in THF (40 mL) at 0 was added a solution of triethyl phosphonoacetate (6.05 g, 5.3 mL, 27.0 mmol) in THF (20 mL) during a period of 5 min. The mixture was kept at 0 for 60 min. Then a solution of 1-chloro-3-iodopropane (2.04 g, 1.05 mL, 10.0 mmol) in THF (20 mL) was added dropwise over a period of 5 min. Then the mixture was kept at room temperature for an additional 24 h. The reaction was quenched by addition of saturated NH4Cl (15 mL), then THF was removed by vacuum distillation. The aqueous phase was extracted with EtOAc (30 mL*3), and washed with brine (40 mL). The combined organic layers were dried over NaSO4 and concentrated. The residue was purified by flash chromatography to give the substitued phosphonoacetate 6 (rotamers in a 1:1 ratio) as a slight yellow oil (2.54 g, 84% yield from the 1-chloro-3-iodopropane 8).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Chloro-3-iodopropane, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Yi, Ming; Gu, Peiming; Kang, Xiao-Yan; Sun, Jian; Li, Rui; Li, Xue-Qiang; Tetrahedron Letters; vol. 55; 1; (2014); p. 105 – 107;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com