Related Products of 610-97-9, A common heterocyclic compound, 610-97-9, name is Methyl 2-iodobenzoate, molecular formula is C8H7IO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: General procedure carbonylative cyclization ofmethyl-2-iodobenoate/1,2-diiodo benzene for the synthesis ofN-substituted isoindole-1,3-diones using ImmPd-IL as a catalystIn a 100 mL stainless steel autoclave, methyl-2-iodobenoate/1,2-diiodobenzene (1 mmol), aryl amine (2 mmol), ImmPd-IL(2 mol%), toluene (10 mL) and Et3N (2.5 mmol) were added. Theautoclave was closed, purged three times with nitrogen followedwith carbon monoxide, and then pressurized with 1 atm of CO andheated at 100C for 6 h. After completion of reaction the reac-tor was cooled to room temperature, the remaining CO gas wascarefully vented, and the reactor was opened. The reactor vesselwas thoroughly washed with ethyl acetate (10-15 mL) to removeany traces of product and catalyst if present. The catalyst was fil-tered and the reaction mixture was evaporated under vacuum. Theresidue obtained was purified by column chromatography (silicagel, 60-120 mesh; petroleum ether/ethyl acetate, 95:05) to affordthe desired product. The products were confirmed by GC, GC-MS,1H NMR and13C NMR spectroscopic techniques. The purity of com-pounds was determined by GC-MS analysis.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Khedkar, Mayur V.; Shinde, Ajinkya R.; Sasaki, Takehiko; Bhanage, Bhalchandra M.; Journal of Molecular Catalysis A: Chemical; vol. 385; (2014); p. 91 – 97;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com