Some common heterocyclic compound, 5100-98-1, name is 3-Chloro-2-iodotoluene, molecular formula is C7H6ClI, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 5100-98-1
To a souton of I nethybenzene (4.0 g, 16 mmo) n CC4 (12 mL), were added Nbromosuccnmde (NBS) (5.6 g, 32 nno) and 11azobs(cycohexanecarbonftre (ABN) (3.9 g, 16 mmo). Then,xture was degassed wfth nitrogen and then heated at 90 °C for I h. After coohng to rt,sHca ge was added, and the sovent was removed in vacuo. Purflcaton (FCC, SO2; 0 ? 5percent EtOAc/hexanes) provded the Ute compound as an o (3.7 g, 70percent yed). 1H NMR(400 MHz, CDC3): 3 7.37 (rn, 2H), 7.29 – 7.23 (m, I H), 4.65 (s, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5100-98-1, its application will become more common.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; RAVULA, Suchitra; SWANSON, Devin M.; SAVALL, Bradley M.; AMERIKS, Michael K.; (250 pag.)WO2016/176449; (2016); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com