Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 127654-70-0, name is 1-Chloro-3-fluoro-2-iodobenzene, A new synthetic method of this compound is introduced below., Computed Properties of C6H3ClFI
1-Chloro-3-fluoro-2-iodobenzene (100 g, 0.39 mol), (5-bromo-2-methoxyphenyl) boronic acid (90.0 g, 0.39 mol) Dissolved in 2000 mL of tetrahydrofuran. To this was added a 2M solution of sodium carbonate (Na2CO3) (750 mL) Tetrakis (triphenylphosphine) palladium (0) (4.5 g, 3.9 mmol) was added and refluxed for 9 hours. After the reaction was completed, the reaction mixture was cooled to room temperature, The water layer was separated and removed, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The mixture was recrystallized from chloroform and ethanol to give Compound A1 (104.9 g, yield 86%, MS: [M + H] + = 315 ).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; LG Chem, Ltd.; Lee Jeong-ha; Park Tae-yun; Jeong Min-u; Lee Dong-hun; Moon Jeong-uk; (77 pag.)KR2018/41607; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com