Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 391211-97-5, name is 3,4-Difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoic acid, A new synthetic method of this compound is introduced below., Product Details of 391211-97-5
A dry 100 mL round bottomed flask was charged with 3,4-difluoro-2-((2-fluoro-4- iodophenyl)amino)benzoic acid, (39) and 5 mL of DCM. The reaction mixture was cooled with an ice-bath to 0 C. 100 of anhydrous DMF was added followed by dropwise addition of neat oxalyl chloride (2 equiv.) over 5 min. The reaction was stirred at 23 C for 4 h. The solvent was then removed under reduced pressure. Excess oxalyl chloride was azeotropically removed with 2 X 5 mL portions of DCM under reduced pressure. The crude product was dissolved into 5 mL of DCM and the appropriate amine was added neat at 0 C. The ice bath was removed after 10 min and the reaction was permitted to warm to room temperature. The reaction was then stirred at 23 C for 6 h; completion of reaction was determined by TLC. A mixture of 10 mL of H20 and 10 mL of Et20 was added and the resultant mixture was extracted with Et20, washed with NaCl (aq, sat), and dried over Na2S04. The extract was decanted and then the solvent was removed under reduced pressure. The crude product was isolated on Si02 using hexane/EA.
The synthetic route of 391211-97-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND; DUQUESNE UNIVERSITY OF THE HOLY GHOST; CHAKRABARTY, Suravi; FLAHERTY, Patrick, T.; MONLISH, Darlene; CAVANAUGH, Jane, E.; BUROW, Matthew, E.; ELLIOTT, Steven; HOANG, Van, T.; WO2015/38743; (2015); A1;,
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