Adding a certain compound to certain chemical reactions, such as: 21304-38-1, name is 4-Iodobenzene-1,2-diamine, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21304-38-1, SDS of cas: 21304-38-1
4-Iodo-l,2- phenylenediamine (0.47 g) and 3-(2-naphthyl)glutaric anhydride (0.48 g) were dissolved in dichloromethane (6 ml) with heating. The dark solution was stirred at rt for 1 h. The precipitate formed was collected by suction filtration, washed with dichloromethane, and dried in vacuo to give a mixture of regioisomeric amides (0.82 g) as light red solid. This solid was dissolved in 4M HCI in 1,4-dioxane (3 ml) and the dark solution was heated to reflux for 1 h. The precipitate formed is isolated by suction filtration of the still hot mixture and washed with 1,4-dioxane, hot acetic acid, and finally diethyl ether to provide 4-(5-iodo-2-benzimidazolyl)-3- (2-naphthyl)butanoic acid HCI (0.71 g) as light red solid. 1H-NMR (500 MHz, DMSOd6)): delta (ppm) = 2.83 (dd, J = 16.1, 8.3 Hz, IH), 2.91 (dd, J = 16.1, 6.4 Hz, IH), 3.57 (dd, J = 14.9, 9.1 Hz, IH), 3.64 (dd, J = 14.9, 7.0 Hz, IH), 4.02 (m, IH), 7.45 (m, 2H), 7.51 (dd, J = 8.6, 2.4 Hz, 2H), 7.72 (dd, J = 8.6, 1.5 Hz, IH), 7.82 (m, 4H), 8.06 (d, J = 1.4 Hz, IH).13C-NMR and DEPT (125 MHz, DMSOd6) : delta (ppm) = 32.64 (CH2), 39.93 (CH2), 39.96 (CH), 89.44 (C), 115.64 (CH), 121.99 (CH), 125.53 (CH), 125.60 (CH), 125.70 (CH), 126.06 (CH), 127.34 (CH), 127.48 (CH), 128.01 (CH), 130.49 (C), 131.96 (C), 132.57 (C), 132.75 (C), 133.67 (CH), 139.23 (C), 152.73 (C), 172.25 (CO).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Iodobenzene-1,2-diamine, and friends who are interested can also refer to it.
Reference:
Patent; UNIVERSITAET DES SAARLANDES; ENGEL, Matthias; FROeHNER, Wolfgang; STROBA, Adriane; BIONDI, Ricardo M.; WO2010/43711; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com