Reference of 181765-86-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 181765-86-6 as follows.
To a solution of 5-Bromo-2-iodo-benzoic acid methyl ester (24 g, 70.4 mmol) and methyl 2,2-difluoro-2- (fluorosulfonyl)acetate (13.5 mL, 105.6 mmol) inN-methyl-2-pyrrolidinone (80 mL) was added copper (I) bromide (1.21 g, 8.45 mmol). The reaction mixture was stirred at 100C for 5 hours. The reaction was filtered and partitioned between ethyl acetate and brine. The aqueous layer was extracted with ethyl acetate, and the organic layers were combined and dried over Na2SO4. After filtration, the solvent was removed in vacuo. The residue waspurified by silica gel column (0-4% Ethyl acetate in Petroleum ether) to give the 5-Bromo-2-trifluoromethyl-benzoic acid methyl ester (119.2 g, yield 96%) as yellow oil.
According to the analysis of related databases, 181765-86-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SANOFI; PASCAL, Cecile; PELLET, Alain; COURTEMANCHE, Gilles; CAMPBELL, Simon; (78 pag.)WO2019/8027; (2019); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com