Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 101066-87-9, name is 4-Iodo-2-(trifluoromethyl)benzonitrile, A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Iodo-2-(trifluoromethyl)benzonitrile
Step A. tert-butyl 3-(4-cvano-3-(trifluoromethyl)phenyl)-3-hvdroxypyrrolidine-l- carboxylate To a mixture of 4-iodo-2-(trifluoromethyl)benzonitrile (946 mg, 2.702 mmol) in THF (5 mL) at 0 C was added a solution of BuLi in hexane (1.29 mL, 3.25 mmol) and stirred under nitrogen for 1 hour. To the mixture at 0 C was added a solution of tert-butyl 3- oxopyrrolidine-l-carboxylate (500 mg, 2.702 mmol) in THF (5 mL) and stirred at room temperature for 4 hours. The reaction mixture was quenched with H20 (20 mL) and extracted with ethyl acetate (20 mL x 2). The extracts were combined, washed with brine (20 mL), dried over sodium sulfate, filtered, and concentrated under reduced pressure to afford tert-butyl 3 -(4-cyano-3 -(trifluoromethyl)phenyl)-3 -hydroxypyrrolidine- 1 – carboxylate as a white solid (368 mg, 38%). LCMS (ESI) m/z: 301.0 [M-56+H]+.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; BEAUFOUR-IPSEN (TIANJIN) PHARMACEUTICAL CO., LTD.; AUVIN, Serge; LANCO, Christophe; DUTRUEL, Oliver; CHAO, Qi; GU, Kaichun; WO2015/100617; (2015); A1;,
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