Reference of 34270-90-1,Some common heterocyclic compound, 34270-90-1, name is 1-Iodo-2-(2-iodoethoxy)ethane, molecular formula is C4H8I2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 35 In 3 ml of dimethylformamide was dissolved 140 mg of 7alpha-[(2,3,6-trideoxy-3-amino-alpha-L-lyxo-hexopyranosyl)oxy]-9alpha-amino-9beta-acetyl-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione (dihydrochloride, m.p. 176-180 C.; [alpha]D25 +149 (c=0.11, water)]. Then, to the solution were added 2.0 g of bis(2-iodoethyl) ether and 72 mg of triethylamine and this was stirred at room temperature overnight. The reaction mixture was poured into a saturated aqueous sodium bicarbonate solution and extracted with chloroform. Thereafter, the chloroform layer was washed with water, dried over sodium sulfate and the solvent was removed by distillation under reduced pressure to obtain a residue. This residue was purified by a silica gel column chromatography (eluant: 10% methanol/chloroform containing 0.5% aqueous ammonia) and then converted to hydrochloride with hydrochloric acid/ether to obtain 98 mg of d-7alpha-[(2,3,6-trideoxy-3-morpholino-alpha-L-lyxo-hexopyranosyl)oxy]-9alpha-amino-9beta-acetyl-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione di-hydrochloride [m.p. 178 -179 C.; [alpha]D20 +156 (c=0.10, methanol)].
The synthetic route of 34270-90-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sumitomo Pharmaceuticals Company; US4673668; (1987); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com