Related Products of 5460-32-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5460-32-2, name is 4-Iodo-1,2-dimethoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.
Step E: A mixture of the intermediate prepared in Step D, (S)-tert-butyl 4-(4-ethynyl- 3-(methoxycarbonyl)phenyl)-2-methylpiperazine-l-carboxylate (716 mg, 2.0 mmol), 4-iodo-l,2- dimethoxybenzene (634 mg, 2.4 mmol), Cul (19.0 mg, 0.1 mmol), PdCl2(Ph3P)2(70 mg, 0.1 mmol), Et3N (0.56 mL, 202 mg, 4.0 mmol) and acetonitrile (2.0 mL) was irradiated in a microwave reactor, under argon at 120 °C for 20 minutes. The mixture was then cooled and chromatographed twice (silica gel, ethyl acetate in hexanes, 0-50percent, then ethyl acetate in dichloromethane, 7.5percent) to give the alkyne intermediate as a yellow oil (367 mg, 37percent). MS m/z 495.3 [M+H]+.
The chemical industry reduces the impact on the environment during synthesis 4-Iodo-1,2-dimethoxybenzene. I believe this compound will play a more active role in future production and life.
Reference:
Patent; PTC THERAPEUTICS, INC.; CHEN, Guangming; DAKKA, Amal; KARP, Gary Mitchell; LI, Chunshi; NARASIMHAN, Jana; NARYSHKIN, Nikolai; WEETALL, Maria L.; WELCH, Ellen; ZHAO, Xin; WO2013/112788; (2013); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com