Adding a certain compound to certain chemical reactions, such as: 112671-42-8, name is 4-Bromo-1-iodo-2-nitrobenzene, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 112671-42-8, name: 4-Bromo-1-iodo-2-nitrobenzene
Intermediate M1 – a (5.1 g, 18.4 mmol) with 2 – iodo -5 – bromo nitrobenzene (15.3 g, 46.7 mmol), sodium tertiary butyl alcohol (7.1 g, 74.4 mmol), toluene 100 ml, nitrogen protection, 0.3 gPd2(Dba)3, Tri-[…] (20 ml, 10% toluene solution), open mixing, heating to 100 C reflux, the reaction 12 h, washing the reaction solution, the organic phase is concentrated, over silica gel column, eluent ethyl acetate is petroleum ether=50 1, concentrated eluent, get midbody M1 – b (9.2 g, yield 73.9%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-1-iodo-2-nitrobenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Beijing Dingcai Technology Co., Ltd.; Gu’an Dingcai Technology Co., Ltd.; Fan Hongtao; Xing Qifeng; Zhang Wei; Zhang Xianghui; (25 pag.)CN107880051; (2018); A;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com