Some common heterocyclic compound, 847685-01-2, name is 4,5-Difluoro-2-iodoaniline, molecular formula is C6H4F2IN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. name: 4,5-Difluoro-2-iodoaniline
A dark violet solution of 2-iodo-4,5-difluoroaniline (1a) (148 mg, 0.582 mmol), gold complex [AuPPh3NN] 2 (308 mg, 0.5 mmol),[Pd(PPh3)4] (52 mg, 0.045 mmol) in 7 ml of acetonitrile were stirred in an argon atmosphere at 60-65 C for 1 h. The reaction mixture was evaporated. The product was isolated by column chromatography on SiO2, using a mixture of methylenechloride with ethylacetate (3:1) as the eluent. Yield: 71 mg (50%), dark purple crystals, Tmelt = 140-141 C. UV spectrum(CH2Cl2), lambdamax, nm (lgepsilon): 240 (4.00), 260 (3.79), 346 (4.07), 578 (2.88). IR spectrum (KBr), v , cm-1: 3357, 3168 (NH2), 2996(C-H), 1646, 1592, 1502, 1355, 1143, 873, 788. Found, %: 55.07, 5.63, N 14.64. Calculated, %: 54.93, 5.63, N14.78.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 847685-01-2, its application will become more common.
Reference:
Article; Tretyakov; Makhneva; Politanskaya; Bagryanskaya, I. Yu.; Stass; Journal of Structural Chemistry; vol. 59; 3; (2018); p. 689 – 696; Zh. Strukt. Kim.; vol. 59; 3; (2018); p. 712 – 719,8;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com