Application of 6213-88-3, The chemical industry reduces the impact on the environment during synthesis 6213-88-3, name is (E)-Methyl 3-iodoacrylate, I believe this compound will play a more active role in future production and life.
General procedure: Under nitrogen condition, Pd(PPh3)2Cl2 (18 mg, 0.025 mmol, 0.05 eq), CuI (6 mg, 0.025 mmol, 0.05 eq) and substrates (0.5 mmol, 1.0 eq) weres uccessively added to a 25 mL vial equipped with a stir bar. Dry THF (5.0 mL) was added using a syringe, then alkenyl iodine compounds (0.6 mmol, 1.2 eq) was added to the mixture. Et3N (150 mg, 1.5 mmol, 3.0 eq) was added at last. The reaction was stirredat 60 C for 12h. Solvent was removed in vacuoto leave a crude mixture, which is purified by silica gel column chromatography to afford pure product (PE:EA = 10:1).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (E)-Methyl 3-iodoacrylate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Chen, Dianpeng; Xing, Gangdong; Chen, Xueyuan; Yao, Jinzhong; Zhou, Hongwei; Tetrahedron Letters; vol. 57; 46; (2016); p. 5124 – 5126;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com