Adding a certain compound to certain chemical reactions, such as: 83863-33-6, name is 5-Iodo-2-methylaniline, belongs to iodides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 83863-33-6, Formula: C7H8IN
To a solution of step-c product (5 g, 0.02 mol) in chloroform (30 ml, 6 times), acetic anhydride (4.96 g, 0.04 mol, 2.27 eq) was added at O0C and the contents were stirred for 1 hr at rt. Progress of the reaction was monitored by TLC (30% ethyl acetate/hexane, Rf-0.7). On completion, potassium acetate (061 g, 0.006 mol, 0.29 eq) followed by isoamyl nitrate (5.3 g, 0.046 mol, 2.1 eq) were added. The overall reaction mixture was heated to a reflux temperature and allowed to reflux for 12 hrs. Progress of the reaction was monitored by TLC (30% ethyl acetate/hexane, Rf-0.7). On completion of the reaction, cooled the reaction contents to rt and the layers formed were separated out. Organic layer was washed with water, dried over sodium sulfate and concentrated under reduced pressure. The crude obtained was purified by column chromatography (silica gel, 15% ethyl acetate/hexane) to yield the required product as an yellow colored solid (2 g, 32.7% yield).
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Reference:
Patent; GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; FRORMANN, Sven; LESCH, Bernhard; LEE, Jeewoo; KIM, Yong-Soo; KIM, Myeong-Seop; WO2010/127855; (2010); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com