Synthetic Route of 25309-64-2,Some common heterocyclic compound, 25309-64-2, name is 1-Ethyl-4-iodobenzene, molecular formula is C8H9I, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To the mixture of [RuCl2(p-cymene)]2 (0.05 equiv), K2CO3 (2 equiv), 1a (1 equiv), 2a (1.5 equiv) and 3 mL NMP were added successively. The mixture was stirred at 120 C for 18 h. The solution was extracted with ethyl acetate (3 x 15 mL), and the combined extract was dried with anhydrous MgSO4. Solvent was removed, and the residue was separated by column chromatography to give the pure sample 3a.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Ethyl-4-iodobenzene, its application will become more common.
Reference:
Article; Cao, Hua; Zhan, Haiying; Shen, Dongsheng; Zhao, Hong; Liu, Yi; Journal of Organometallic Chemistry; vol. 696; 19; (2011); p. 3086 – 3090;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com