Electric Literature of 340825-13-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 340825-13-0, name is 6-Iodo-3,4-dihydronaphthalen-1(2H)-one, This compound has unique chemical properties. The synthetic route is as follows.
A 200 mL round bottom flask was charged with Compound 6 (4.1 g, 15 mmol),Methanol (100 mL) was added, and at 0 C. under ice cooling,Sodium borohydride (850 mg, 22.5 mmol) was gradually added,The mixture was stirred at 0 C. for 3 hours.The excess sodium borohydride was neutralized with dilute hydrochloric acid, saturated brine was added,Extraction was carried out 5 times with ethyl acetate (50 mL).The extract was washed once with ammonium chloride (100 mL)Subsequently, the solution was washed twice with saline (100 mL), dried over sodium sulfate.The filtrate was concentrated, as a pale red solid,Compound 7 was obtained (yield 3.93 g, yield 95.5%).This was used as it was for the next reaction without further purification.
The chemical industry reduces the impact on the environment during synthesis 6-Iodo-3,4-dihydronaphthalen-1(2H)-one. I believe this compound will play a more active role in future production and life.
Reference:
Patent; RICOH COMPANY LIMITED; GOTO, DAISUKE; YAMAMOTO, SATOSHI; MIYAGAWA, SATOSHI; KATO, TAKUJI; MOHRI, MASATAKA; NAKANOTANI, HAJIME; (65 pag.)JP6146001; (2017); B2;,
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