Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14452-30-3, name is 1-(3-Iodophenyl)ethanone, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-(3-Iodophenyl)ethanone
Step A: 4-(3-Iodo-phenyl)-2,4-dioxo-butyric acid methyl ester Sodium hydride (60% oil dispersion, 4.9 g, 123 mmol) was added in portions to a solution of 3-iodoacetophenone (25.18 g, 102.3 mmol) and dimethyl oxalate (14.5 g, 123 mmol) in DMF (125 mL) at 0 C. The mixture stirred at room temperature for 1 hour and was then heated at 115 C. for 1 h. After cooling, the mixture was treated with 3 M HCl and then diluted with ethyl acetate. The organic layer washed three times with water and saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated. Chromatography on silica gel, 0-10% ethyl acetate in hexanes, afforded 24.2 g of the subtitle compound (71.3% yield) as a yellow solid which was used directly in the next step.
According to the analysis of related databases, 14452-30-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AstraZeneca AB; NPS PHARMACEUTICALS, INC.; US2007/259895; (2007); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com