Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 34270-90-1, name is 1-Iodo-2-(2-iodoethoxy)ethane, A new synthetic method of this compound is introduced below., Recommanded Product: 34270-90-1
Step D: 4-(4-(2-((2,6-difluorobenzyl)oxy)-l , 1 ,1 ,3,3,3-hexafluoropropan-2-yl)phenyl)-4- ((4-fluorophenyl)sulfonyl)tetrahydro-2H-pyran Sodium hydride (13.27 mg, 0.332 mmol, 60%> suspension in mineral oil) was added to a solution of l,3-difluoro-2-(((l,l,l,3,3,3-hexafluoro-2-(4-(((4- fluorophenyl)sulfonyl)methyl)phenyl)propan-2-yl)oxy)methyl)benzene (18 mg, 0.033 mmol) and l-iodo-2-(2-iodoethoxy)ethane (32.4 mg, 0.100 mmol) in N,N- dimethylformamide (1 mL). After 1 h at room temperature, the reaction was complete as judged by LCMS analysis. The mixture was quenched with saturated ammonium chloride (1 mL), diluted with ethyl acetate (20 mL), washed with water (2×5 mL), brine (5 mL), dried (magnesium sulfate), filtered and concentrated under reduced pressure. Silica gel chromatography, eluting with 5-40% ethyl acetate in hexanes, gave Example 1 as white solid (17.4 mg, 81% yield). LC/MS (M+18): 630.1 ; LC retention time: 4.541 min (analytical HPLC Method A); 1H NMR (400 MHz, CDC13) delta ppm 7.63 (d, J=8.4 Hz, 2H), 7.44 – 7.31 (m, 3H), 7.28 – 7.19 (m, 2H), 7.03 – 6.89 (m, 4H), 4.73 (s, 2H), 4.07 – 3.96 (m, J=l 1.8, 1.7 Hz, 2H), 3.37 (t, J=1 1.2 Hz, 2H), 2.77 – 2.62 (m, 2H), 2.45 (d, J=12.3 Hz, 2H).
The synthetic route of 34270-90-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; DUAN, Jingwu; DHAR, T.G. Murali; JIANG, Bin; KARMAKAR, Ananta; GUPTA, Arun Kumar; LU, Zhonghui; WO2015/103510; (2015); A1;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com