Reference of 887266-99-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 887266-99-1, name is 3-Fluoro-4-iodobenzonitrile belongs to iodides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
General procedure: To a solution of ReIO2(PPh3)2 (10 mol %) in toluene (3 mL) were added the nitrile (1 mmol) and PhSiH3 (300 mol %). The reaction mixture was stirred at reflux temperature under air atmosphere and the progress of the reaction was monitored by TLC or 1H NMR. Upon completion, the reaction mixture was cooled to ambient temperature, stirred with charcoal during 3 min and then filtered through a plug of alumina/Celite. To the filtrate was added an ethereal solution of HCl (1.5 mol) to induce the precipitation of amine hydrochloride salts. The solids were isolated upon filtration and then washed with n-hexane to afford the pure amine hydrochloride salts, which are all known compounds.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-4-iodobenzonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Cabrita, Ivania; Fernandes, Ana C.; Tetrahedron; vol. 67; 42; (2011); p. 8183 – 8186;,
Iodide – Wikipedia,
Iodide – an overview | ScienceDirect Topics – ScienceDirect.com